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Dr. Candice Ulmer, Research Chemist, CDC “The Development of Routine and Reference Measurement Procedures to Support the Accurate Reporting of Clinical Measurements” Date: February 23rd, 2021 Time: 5:30 PM EST Zoom: link provided via email or contact badu-tawiah.1@osu.edu

Dr. Michael Wleklinski, Senior Scientist, Merck & Co. “High Throughput Synthesis and Screening: My Journey from Academia to Industry” Date: December 8, 2021 Time: 5:30 PM EST Zoom: link provided via email or contact badu-tawiah.1@osu.edu

Prof. Julia Laskin, Purdue University “Ambient imaging of biological samples using nanospray desorption electrospray ionization (nano-DESI) mass spectrometry” Date: December 8, 2020 Time: 5:30 PM EST Zoom: link provided via email or contact badu-tawiah.1@osu.edu

Biological molecules interact with silica (SiO(2)) surfaces with binding affinities that greatly vary depending on their physical-chemical properties. However, the quantitative characterization of biological compounds adsorbed on silica surfaces, especially of compounds involved in fast, reversible interactions, has been challenging, and the driving forces are not well understood. Here, we show how carbon-13 NMR spin relaxation provides quantitative atomic-detail information about the transient...

Biological molecules interact with silica (SiO(2)) surfaces with binding affinities that greatly vary depending on their physical-chemical properties. However, the quantitative characterization of biological compounds adsorbed on silica surfaces, especially of compounds involved in fast, reversible interactions, has been challenging, and the driving forces are not well understood. Here, we show how carbon-13 NMR spin relaxation provides quantitative atomic-detail information about the transient...

Proanthocyanidins (condensed tannins) are important in food chemistry, agriculture, and health, driving demand for improvements in structure determination. We used ultrahigh resolution Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) methods to determine the exact composition of individual species in heterogeneous mixtures of proanthocyanidin polymers from Sorghum bicolor grain and Neptunia lutea leaves. Fragmentation patterns obtained with FT-ICR ESI MS-MS (electrospray...

Proanthocyanidins (condensed tannins) are important in food chemistry, agriculture, and health, driving demand for improvements in structure determination. We used ultrahigh resolution Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) methods to determine the exact composition of individual species in heterogeneous mixtures of proanthocyanidin polymers from Sorghum bicolor grain and Neptunia lutea leaves. Fragmentation patterns obtained with FT-ICR ESI MS-MS (electrospray...

1. Dr. Maya Reimi Sipala, Scientist at Balazs NanoAnalysis, “HR-ICP-MS Applications in the Semiconductor Industry” Date: November 17, 2020 Time: 5:30 PM EST Zoom: to be provided via email

Prof. Peter Nemes, University of Maryland, “Single-cell Mass Spectrometry Discovers Metabolic Effectors of Cell Differentiation” Date: November 2, 2020 Time: 4:10 PM EST Place: Zoom – link provided via email or contact badu-tawiah.1@osu.edu

Cyclic peptides are capable of binding to challenging targets (e.g., proteins involved in protein-protein interactions) with high affinity and specificity, but generally cannot gain access to intracellular targets because of poor membrane permeability. In this work, we discovered a conformationally constrained cyclic cell-penetrating peptide (CPP) containing a d-Pro-l-Pro motif, cyclo(AFΦrpPRRFQ) (where Φ is l-naphthylalanine, r is d-arginine, and p is d-proline). The structural constraints...

Cyclic peptides are capable of binding to challenging targets (e.g., proteins involved in protein-protein interactions) with high affinity and specificity, but generally cannot gain access to intracellular targets because of poor membrane permeability. In this work, we discovered a conformationally constrained cyclic cell-penetrating peptide (CPP) containing a d-Pro-l-Pro motif, cyclo(AFΦrpPRRFQ) (where Φ is l-naphthylalanine, r is d-arginine, and p is d-proline). The structural constraints...

1. Prof. Carlito Lebrilla, Department of Chemistry, UC Davis “Carbohydrates as biomarkers for health and diseases” Date: October 13, 2020 Time: 5:30 PM (EST) Zoom: to be provided

The title compound, C(16)H(20)N(2) ^(2+)·2Br^(-)·H(2)O (1) is a member of the class of compounds called viologens. Viologens are quaternary salts of di-pyridyls and are especially useful as redox indicators as a result of their large negative one-electron reduction potentials. Compound 1 consists of a dication composed of a pair of 4-methyl-pyridine rings mutually joined at the 2-position, with a dihedral angle between the pyridine rings of 62.35 (4)°. In addition, the rings are tethered via the...

The title compound, C(16)H(20)N(2) ^(2+)·2Br^(-)·H(2)O (1) is a member of the class of compounds called viologens. Viologens are quaternary salts of di-pyridyls and are especially useful as redox indicators as a result of their large negative one-electron reduction potentials. Compound 1 consists of a dication composed of a pair of 4-methyl-pyridine rings mutually joined at the 2-position, with a dihedral angle between the pyridine rings of 62.35 (4)°. In addition, the rings are tethered via the...

1. Dr. Mike Freitas “Moving mass Spectrometry informatics into the cloud. A case study report on the implementation of AWS cloud based workflows for mass spectrometry data analysis.” Date: Sept 15th Time: 5:30pm Place: Zoom – link to be provided via email

The quantitative and comprehensive description of the internal dynamics of proteins is critical for understanding their function. Nanoparticle-assisted ^(15) N NMR spin relaxation spectroscopy is a new method for the observation of picosecond to microsecond dynamics of proteins when transiently interacting with the surface of the nanoparticles (NPs). The method is applied here to the protein ubiquitin in the presence of anionic and cationic silica NPs (SNPs) of different sizes. The backbone...

The quantitative and comprehensive description of the internal dynamics of proteins is critical for understanding their function. Nanoparticle-assisted ^(15) N NMR spin relaxation spectroscopy is a new method for the observation of picosecond to microsecond dynamics of proteins when transiently interacting with the surface of the nanoparticles (NPs). The method is applied here to the protein ubiquitin in the presence of anionic and cationic silica NPs (SNPs) of different sizes. The backbone...

Intrinsically disordered proteins (IDPs) can display a broad spectrum of binding modes and highly variable binding affinities when interacting with both biological and nonbiological materials. A quantitative model of such behavior is important for the better understanding of the function of IDPs when encountering inorganic nanomaterials with the potential to control their behavior in vivo and in vitro. Depending on their amino acid composition and chain length, binding properties can vary...

Intrinsically disordered proteins (IDPs) can display a broad spectrum of binding modes and highly variable binding affinities when interacting with both biological and nonbiological materials. A quantitative model of such behavior is important for the better understanding of the function of IDPs when encountering inorganic nanomaterials with the potential to control their behavior in vivo and in vitro. Depending on their amino acid composition and chain length, binding properties can vary...

In keeping with directions provided by the University in regards to corona virus pandemic, MSDG meetings will be suspended for the remainder of the semester. All speakers have been notified of this change