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Mass Spec and Proteomics > Instruments

List of Instrumentation for the CCIC MS&P Lab

Feel free to ask our staff members to show you the lab during your next visit.

Instrument Managers
Nan Kleinholz: Amazon, MALDI TOF-TOF
Liwen Zhang: Thermo Fusion
Sophie Harvey: Bruker timsTOF Pro
Matt Bernier: Agilent, Quantiva, and QE-Metabolomics
Andrew Reed: QE-Proteomics
Arpad Somogyi: Bruker 15T FT-ICR
 

Bruker 15 Tesla FT-ICR mass spectrometer

https://www.ccic.osu.edu/MSP-Acknowledging
Ultrahigh resolution (>1,000,000) and mass accuracy (< 1 ppm). Equipped with a dual ionization source (MALDI and ESI). ETD and ECD options available. Used mostly for untargeted metabolomics, small molecule MALDI imaging, and top down proteomics.

Bruker FT-ICR

 

Thermo Orbitrap Fusion HPLC-MS/MS System

Ultrahigh resolution and excellent mass accuracy. Used mostly for bottom-up proteomics.

 

Thermo Fusion

 

Thermo Quantiva Triple Quadrupole HPLC MS/MS System

Ultrahigh sensitivity, used mostly for quantitative (targeted) metabolomics

 

Thermo Quantiva

 

Bruker amaZon ETD

Ultra performance, high sensitive proteomics ion trap with dual funnel ion guide and advanced ETD / PTR capabilities (Electron Transfer Dissociation and Proton Transfer Reaction) with a Dionex U3000 RSLC system.

 

Bruker Amazon

 

 

 

Bruker ultrafleXtreme MALDI-TOF-TOF MS with Proteineer fc II for LC-MALDI and ImagePrep

The Bruker-Daltonics UltrafleXtreme MALDI-TOF-TOF MS-Tissue Imaging Platform with collision- induced dissociation (CID) capabilities for structural determination by MALDI

 

Bruker Malldi

 

 

Thermo Scientific LTQ Orbitrap

A LTQ Orbitrap XL exclusively used for advanced proteomic projects that require high resolution and high mass accuracy. This instrument is a unique hybrid mass spectrometer that combines a linear ion trap and an orbitrap mass analyzer. The system come equipped with a microspray ionization source from Michrome Bioresources and comprehensive U3000 Cap-LC system from Dionex .

 

Thermo XL

 

 

 

Agilent 6545 Quadrupole Time of Flight LC-MS system

The Agilent 6545 QTOF is equipped with two Agilent 1290 UHPLC systems, one for reverse phase and one for normal phase separations. This instrument is designed for high resolution and broad profiling of unknown compounds in untargeted metabolomics studies. The extended TOF flight tube and SWARM autotuning allows for both high sensitivity and dynamic range, offering ideal specifications for complex sample analysis.

 

Agilent QTOF

 

 

Bruker timsTOF Pro HPLC-MS/MS with Ion Mobility (on Loan from Bruker Daltonics)

High resolution TOF analysis/sequencing of peptides separated by trapped ion mobility prior MS/MS fragmentation. The instrument has high duty cycle (almost 100%) and high sensitivity (200-250 ng of proteins). Large numbers of proteins can be identified in complex protein mixtures containing 5,000+ proteins. This instrument was provided by Bruker on a one year loan.

 

Bruker timsTOF

 

 

Thermo Scientific QE Plus (Proteomics, QE-P)

Ultrahigh resolution and excellent mass accuracy. Used almost exclusively for bottom-up proteomics.

 

Thermo QE Proteomics

 

Thermo Scientific QE Plus (Metabolomics, QE-M)

Ultrahigh resolution and excellent mass accuracy. This QE plus is exclusively used for untargeted andtargeted metabolomics.

 

Thermo QE Metabolomics